Аңдатпа
The introduction of modern technologies in traumatology and orthopedics, such as immersion fixators and new biometallic alloys, has led to a qualitative change in approaches to treatment, but the use of new materials in the manufacture of implants remains relevant.Purpose of the study. Study of the biocompatibility of an alloy of titanium, tantalum and niobium (Ti21Nb6Ta) in vitrо. Methods. The study examined the toxic effects of aqueous extracts of TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) on human fibroblasts and periosteal cells in vitro using the MTT test; hemolytic activity of TNT and BT-6 alloys on the blood of experimental animals - Wistar rats (in vitro) by spectrophotometry; Pyrogenic activity was also studied using the kinetic chromogenic method. The object of the study is the metal alloys TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) (control group).Results. In vitro studies have shown that aqueous extracts from the metal alloys TNT and BT-6 do not have a cytotoxic effect on cultured human fibroblasts and periosteal cells in vitro. It was revealed that aqueous extracts of TNT and BT-6 alloys do not have hemolytic and pyrogenic activity.Conclusions. The studies conducted indicate a high level of safety and biocompatibility of the TNT alloy, which is proven by a set of in vitro tests. Thus, according to the generally accepted hygienic classification, the metal alloys TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) can be classified as hazard class 4 - low-hazard substances (GOST 12.1.007-76).