Аңдатпа
Background and Aim: A recent analysis of anti-HBc prevalence within Kazakhstan blood donors' population concluded a 17.2% rate.Considering these data are among the highest of infectivity results worldwide, this study sought to define an association of positive Hepatitis B serology markers with risk and behavior factors.Methods: The blood donors' samples were tested for anti-HBcore total (IgG/IgM) and anti-HBs, by CLIA on the Architect i2000SR platform (Abbott).Surrogate alanine transferase (ALT) markers for all blood donors were tested by kinetic method on the A25 analyzer (Biosystems).A questionnaire was developed to obtain the donors' socio-demographic characteristics, nutrition habits, cholesterol levels, history of smoking and alcohol consumption.Informed consent was obtained from all study participants.Statistics were calculated using the R software program (version 4.1.1,USA, 2021).Results: A group of 5709 blood donors participated in the study.Participants with positive for anti-HBc were on average older (41.8 vs 34.4 years, p<0.001),Kazakh (88.7% vs 83.0%, p<0.001), married (74.0%vs 55.6%, p<0.001), had a secondary education (70.1% vs. 59.4%, p=0.03), smoked (27.9% vs. 24.3%,p=0.05), had a longer smoking history (13.6±9.5 years vs. 9.8±8.5 years, p<0.001), and various hypercholestesterolaemia (6.2% vs 3.9%, p=0.02).Predominantly their main meal was dinner (17.0%vs 14.2%, p=0.03).Analysis for associations of socio-demographics characteristics, risk factors, and nutrition with anti-HBs, showed that those who have secondary education level (70.1%) were more likely to be anti-HBs-positive (p=0.03).No other significant correlations for anti-HBs were observed.Conclusions: The risk factors and behavior analysis highlighted the blood donors' overall health status.Positive Hepatitis B markers associated with statistically significant characteristics from socio-demography, nutrition habits or risk factors could support further pathogenesis studies looking for HBV treatment guides fulfilling the existing gaps.