Аңдатпа
The article shows the achievements of the last decades, which led to the emergence of new directions in the manufacture of medicines, to the revision and reassessment of a number of theoretical positions and traditional techniques. The most significant influence on the development of dosage forms was the establishment of the dependence of the therapeutic effect of medicinal substances not only on the chemical structure and physiological activity, but also on other factors, such as the technology of drug manufacture, the degree of dispersion of medicinal substances, their physical condition, the type of dosage form, etc. The rational way to find new drugs, namely antiparasitic ones, is still to vary the structure of the molecules of known chemical compounds, for example, avermectins, and to optimize them-to strengthen the desired and weaken the side effect by creating a dosage form. Until recently, the dosage form was considered from the point of view of its compliance with purely technological requirements, i.e., as a more or less convenient form of the active substance that has the appropriate properties: particle size, consistency, hardness, fusibility, flowability, surface appearance, smell, taste, mass. At the same time, the dosage form has a significant effect on the effect of the drug substance included in it. It is the whole set of properties, and not only the active substance, affects a certain process in the body.