Аңдатпа
Synthesis and structure of condensed biheterocycles on the basis of 3-amino-1,2,4-triazoleThe article is devoted to the development of preparatively convenient methods for the synthesis of new derivatives of 3-amino-1,2,4-triazole with the aim of constructing new condensed systems of industrially important substances.The synthesis of triazolopyrimidines, prepared by three-component condensation of 1,3-dicarbonyl compounds (anilide of acetoacetic acid and acetoacetic ether) with substituted aromatic aldehydes and 3-amino-1,2,4-triazole.It is shown that by melting at 120-140 ºC, in the absence of a solvent in equimolecular amounts of acetylacetyl anilide and acetoacetic ether with a mixture of 3-amino-1,2,4-triazole and substituted aromatic aldehydes (3-ethoxy-4-hydroxybenzaldehyde, salicylic aldehyde), leads to the 7-aryl-5methyl-N-phenyl-4,7-dihydro-[1,2,4-triazolo][1,5-a]pyrimidine-6-carboxamides and ethyl 7-aryl-5-methyl-4,7-dihydro-[1,2,4-triazolo][1,5-a]pyrimidin-6-carboxylate-titrate respectively.The structures of the synthesized compounds were studied by 1 H and 13 C NMR spectroscopy, as well as with the data of the twodimensional spectra of COSY ( 1 H-1 H) and HMQC ( 1 H-13 C).The values of chemical shifts, multiplicity and integrated intensity of the 1 H and 13 C signals in one-dimensional NMR spectra are determined.Homo-and heteronuclear interactions were established using spectra in the formats COSY ( 1 H-1 H) and HMQC ( 1 H-13 C), confirming the structure of the compounds under study.