Аңдатпа
Purpose: The study of association of polymorphisms IL17A gene (rs8193036; rs2275913) with brucellosis. Methods & Materials: Study Design: Case-control. Group of cases - 89 patients with brucellosis, and the control group was 414 people who did not suffer from brucellosis. Genotyping of IL17A (rs8193036; rs2275913) was carried out by the Real-time PCR method in the Organic synthesis laboratory of the “National Center of Biotechnologies”, Astana, Kazakhstan. Statistical calculations were carried out on a calculator for genetic calculations under the Gene Expert program. (http://gen-exp.ru/calculator_or.php). Results: It has been established that the factors predisposing to brucellosis can be the C allele and the CC genotype (OR (95% CI) = 4.42 (3.00-6.51) and 7.32 (4.39-12.20), respectively), and T allele, CT and TT genotypes of polymorphism rs8193036 of the gene IL17A (OR 95% CI) = 0.23 (0.15-0.33), OR (95% CI) = 0.43 (0.26-0, 72) and 0.19 (0.09-0.43), respectively) - the factors of resistance. Studies on the association of polymorphism rs2275913 of the IL17A gene revealed that the factors of predisposition to brucellosis are G and GG (OR (95% CI) = 2.26 (1.51-3.38) and 2.25 (1.40-3.61)), respectively, while the resistance factors may be the allele A (OR (95% CI) = 0.44 (0.30-0.66)) and the AA genotype (OR 95% CI) = 0.08 (0.01-0.61)). Conclusion: The results of our study indicate that in brucellosis there is a possible association of brucellosis with polymorphisms of the IL17A gene (rs8193036, rs2275913).