Аңдатпа
Morphological changes of organ of immune system in chronic influence of Hexavalent chromium are researched well but they are not showed in acute poisoning.The goal of our research was the studying of pathomorphological changes of thymus and spleen in the influence of hexavalent chromium in the acute experiment.Materials and Methods of Research: Male rats, weighing 200,0±20,0g, were oral dosed one time: the control group (30) -1ml of saline, the experimental group (30) -hexavalent chromium at a dose of 75mg /kg (LD 50) in the form of potassium dichromate .The rats were taken out of experiment on first, third and seventh days.The histological specimen was colored by hematoxylin and eosin, azure II-eosin.The received data were processed by statistical program Biostat Exc.Results of Research: 40% of experimental rats died on the 1 st day and 10% of experimental rats died on the third day.Thymus weight was reduced in 3 rd and 7 th day-in 2 times, and spleen weight was increased in 1.3 times in comparison with the control.There was a focal and extensive necrosis in the cortical thymus, in the medulla -petechial and extensive hemorrhages; increase in cell number in a state of degradation focal accumulations haemosiderin; formation of segments with lymph follicular hyperplasia was observed.In the vessels of thymus haemolysis of erythrocytes, plasma and soaking fibrinoid swelling of the walls of the arteries was observed.In the spleen focal and extensive hemorrhage; focal necrosis in the white pulp; in the red pulp numerous focal accumulations of hemolyzed red blood cells, haemosiderin was observed. Conclusion:The development of a mixed dystrophy (parenchyma-mesenchymal)-total haemosiderosis with the development of splenomegaly was observed in the thymus and spleen of experimental rats.