Аңдатпа
Drug delivery systems based on polyurethane have been used for the controlled release of chemotherapeutic agents for the treatment of the chronic microbial disease tuberculosis. The drugs used in the investigation were isoniazid, ethionamide and florimicin. An in vitro technique was used to determine the release characteristics of the drugs into model biological media. It was shown that drug release occurs in accordance with first-order kinetics. The influence of drug loadings on release profiles was studied. The possibility of application of the drug delivery systems for tuberculosis treatment was shown by some medical and biological tests. © 1997 SCI