Аңдатпа
Abstract New ammonium hydrazones have been synthesized by the reaction of Girard’s reagents T and P with isatin derivatives that contain various alkyl or geranyl substituents in position 1. A pronounced anti-anthropo- and antiphyto-pathogenic effect of resulting compounds has been revealed. The n-octyl and octadiene derivatives have the highest selectivity for resistant strains of Staphylococcus aureus when there is no negative effect on the hemostasis system. The aggregation and adsorption properties of the compounds have been studied using tensiometry, conductometry, and UV spectroscopy. The found values of the critical micelle concentration of amphiphilic ammonium hydrazones are an order of magnitude lower than those of quaternary ammonium salts.