Аңдатпа
Background. Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. According to various studies, one of the factors contributing to the development and progression of NAFLD is vitamin D deficiency and insufficiency. Objective. To investigate the interrelationships between clinical and laboratory-instrumental markers of fibrosis activity as well as disturbances in lipid and carbohydrate metabolism in patients with NAFLD before and after completing a course of vitamin D supplementation. Materials and Methods. The study included 121 patients with NAFLD who received vitamin D supplements due to diagnosed deficiency or insufficiency. Anthropometric, laboratory, and instrumental indicators were measured before and after the course of vitamin D therapy. Results. After the treatment, most patients demonstrated a statistically significant increase in vitamin D levels (p < 0.001) and improvement in lipid and carbohydrate metabolism. Mean body mass index, waist circumference, triglyceride levels, and insulin levels decreased significantly (p < 0.05). Additionally, correcting vitamin D deficiency and insufficiency contributed to improvements in liver markers, such as ALT, AST, and composite indices. Conclusion. The obtained data confirm a high prevalence of lipid and carbohydrate metabolic disorders among patients with NAFLD. Vitamin D supplementation significantly improves a range of clinical and laboratory parameters (BMI, WC, AST, albumin, glucose, FLI) in NAFLD patients, emphasizing the need for timely correction of vitamin D insufficiency and deficiency as part of comprehensive NAFLD treatment.