Аңдатпа
Introduction. Aminopropylimidazole derivatives, which potentially can have various pharmacological activities and have a wide range of applications in pharmacochemistry, were selected as the object of study. Aim. The study aimed to investigate some biological effects of new aminopropylimidazole derivatives. In this study, we investigated the acute toxicity and local anesthetic activity in an experiment on laboratory animals. Materials and Methods. The study of the acute toxicity of the compounds was conducted on healthy, sexually mature, non-linear mice. The study of local anesthetic activity during infiltration anaesthesiawas carried out using the method of Bulbring and Wajda on male guinea pigs. The tail flick method was used for the experimental study of local anesthetic activity during conduction anaesthesia. Results. The compounds showed low toxicity, as well as a positive effect of varying degrees of expression during the study of local anesthetic activity in models of conduction and infiltration anaesthesia, exceeding the indicators of novocaine. Conclusion. The obtained results may become the basis for further in-depth study of these compounds within the framework of expanded preclinical trials, including the study of chronic toxicity and the determination of optimal therapeutic doses, with the aim of creating new local anesthetic agents. Key words: aminopropylimidazole derivatives, toxicity, local anaesthetic activity, conduction anaesthesia, infiltration anaesthesia.