Аңдатпа
Background: Eosinophilic infiltration is frequently observed in ulcerative colitis (UC), but its impact on disease course remains incompletely understood. This study aimed to assess eosinophilic infiltration of the colonic mucosa in patients with newly diagnosed UC and to investigate its association with the achievement of clinical remission during the first year of follow-up. Methods: A retrospective study was conducted in patients with newly diagnosed UC. Patients were stratified into two groups according to clinical outcome during the first year of follow-up: clinical remission (n = 30) and non-remission (n = 30). Clinical and laboratory data were extracted from an integrated medical information system database. Archived colonic mucosal biopsy specimens were independently evaluated by two pathologists. Mean eosinophil density across five high-power fields and peak eosinophil count were assessed. Results: In primary biopsy specimens, the median eosinophil density was 19 (11 to 27) cells in the clinical remission group and 33 (23 to 51) cells in the non-remission group. Logistic regression analysis showed that an increased eosinophil count (OR 6.48; 95% CI 1.76 to 23.88; p = 0.005) and the presence of extraintestinal manifestations (OR 5.78; 95% CI 1.17 to 28.6; p = 0.031) were associated with failure to achieve clinical remission during the first year of treatment. Conclusions: In adult patients with ulcerative colitis, a higher density of eosinophils in the colonic mucosa at the time of initial diagnosis is associated with failure to achieve clinical remission during the first year of treatment. These results should be considered hypothesis-generating and require confirmation in larger prospective studies to further clarify the potential prognostic significance of tissue eosinophilia in ulcerative colitis.