Аңдатпа
Increasing evidence suggests that abdominal fat distribution is a greater predictor of metabolic risk (MetS) than BMI. This study aimed to evaluate the 10-year cardiometabolic consequences of isolated abdominal obesity (IAO) and its association with MetS and health-related quality of life (HRQoL). This longitudinal cohort study included 552 adults from the Turkestan region of Kazakhstan who underwent baseline assessment in 2014 and follow-up examination in 2024. Anthropometric, clinical, and laboratory parameters were measured, and the HRQoL was assessed by the SF-36 questionnaire. At baseline, 403 participants (73%) had IAO, and 149 (27%) did not. Participants with IAO were older (45 vs. 37 years, p < 0.001) and more frequently female (79%). They had higher body weight, waist circumference, BMI, blood pressure, and unfavorable metabolic parameters, including higher cholesterol, triglyceride, and glucose levels (all p < 0.05). Metabolic syndrome was more prevalent in the IAO group (30% vs. 1%, p < 0.001). After 10 years, IAO was observed in 472 participants: 97% of those with IAO at baseline remained obese, compared with 54% of those without baseline obesity who developed it ( p < 0.001). Baseline IAO independently predicted incident metabolic syndrome (OR adj = 1.34; p = 0.041). Participants with persistent IAO had lower HRQoL scores in physical functioning, general health, and mental health than individuals without IAO ( p < 0.05). Persistent isolated abdominal obesity was associated with lower health-related quality of life and independently predicted metabolic syndrome over the 10-year follow-up period. These results highlight the importance of assessing abdominal adiposity in clinical practice.