Аңдатпа
A pharmaceutical development of an ointment based on a thick extract of Filipendula vulgaris M. obtained by ultrasonic extraction has been carried out. The use of ultrasonic treatment made it possible to increase the efficiency of extracting biologically active substances, reduce extraction time, and preserve thermolabile components of the plant material. The chemical composition of the thick extract was studied using gas chromatography–mass spectrometry (GC/MS). The analysis revealed the presence of a complex of phenolic compounds, flavonoids, organic acids, esters, and other secondary metabolites with pronounced antioxidant and antiinflammatory activity. The obtained data confirm the pharmacological significance of the extract and the feasibility of its use as an active ingredient in the development of soft dosage forms. Based on the studied extract, five model compositions of the ointment were developed, differing in the ratio of base components and the concentration of the active substance. Each model was evaluated for physicochemical, organoleptic, and rheological characteristics. Parameters such as consistency, resistance to delamination, pH, viscosity, and uniformity of extract distribution in the ointment mass were determined. According to the totality of the obtained data, the optimal composition was identified, providing structural stability and pharmaco-technological properties that meet the requirements for soft dosage forms. Toxicological studies and pharmacological tests of the developed samples were carried out. No signs of acute toxicity or irritating effects were observed during topical application. Experimental evaluation of anti-inflammatory activity demonstrated a significant reduction of inflammatory reactions, indicating a pronounced therapeutic potential of the developed ointment. Thus, the study results confirm that the thick extract of Filipendula vulgaris M. is a promising herbal source of biologically active substances for the development of soft dosage forms with antiinflammatory properties. The developed ointment composition is characterized by stability, safety, and pharmacological efficacy, making it a potential basis for further preclinical and technological studies aimed at pharmaceutical implementation.