Аңдатпа
Introduction. The search for new biologically active compounds remains one of the key goals in medicinal chemistry. The goal of the present study to synthesize two groups of compounds: derivatives of methoxyphenethylamine and imidazolpropylamine with a mandatory N-benzylbispidine backbone and evaluate their potential as plant growth regulators and myelostimulators. Results and Discussion: New series of 3,7-diazabicyclo[3.3.1]nonan-9-ones were synthesized using traditional methods. The structure of the obtained compounds was confirmed using nuclear magnetic resonance (NMR) spectroscopy, infrared spectroscopy, and elemental analysis. Conclusion. New bicyclic systems have been synthesized in order to identify compounds with high biological potential. The myelostimulating activity of the obtained compounds 5βCD, 6βCD was evaluated in laboratory white female rats and growth-stimulating activity in wheat and soy seeds. The results of the study of myelostimulating activity showed that an imidazole derivative, namely the complex 6βCD, at a dose of 5 mg/kg in a volume of 0.5 ml, exhibits moderate activity against leukocytopoiesis, erythrocytopoiesis and thrombocytopoiesis. The results of the study of growth-stimulating activity showed that the complex (5βCD, HZR-112) stimulates plant growth on soybean seed seedlings. However, the complex (6βCD, HZR-109) does not stimulate the growth of wheat and soybeans, but is an inhibitor. It turned out that the combination of the bispidin fragment with methoxyphenethyl or imidazolepropyl is very promising for the search for new biologically active substrates of various types of action.