Аңдатпа
This study evaluated the biological and chemical properties of a new synthetic polymer, glycoluryl-melamine-formaldehyde resin (GUMEFR), obtained using different plasticizers such as hydrochloric (HCl) and oxyethylenediphosphonic acid (OEDP). Special attention was paid to the determination of hemolytic activity, antibacterial properties and free formaldehyde content in the obtained samples, since these parameters are of key importance for the possible application of the material in biomedical and industrial applications. The free formaldehyde content in the GUMEFR samples differed depending on the plasticizer used. The samples obtained using concentrated HCl showed the highest formaldehyde concentration, which amounted to 1.29 wt%. This fact indicates that the choice of plasticizer significantly affects the chemical composition of the final product and may influence its subsequent biological properties. In addition to chemical analysis, the biological properties of the obtained samples, such as hemolytic and antibacterial activity, were investigated. The results showed that all GUMEFR samples had low hemolytic activity, indicating the potential biocompatibility of the material. According to ISO 10993-4:2017, these samples can be classified as hemocompatible, confirming their potential suitability for medical applications such as implants or other medical devices that interact with blood. The antibacterial activity of all tested samples was at a high level, which is presumably due to the release of formaldehyde from the GUMEFR polymer structure into the growth medium. The high antibacterial activity opens up the possibility of using the material in areas requiring protection against bacterial contamination, such as in the production of packaging for medical devices or in the food industry. In addition, given the combination of high hemocompatibility and significant antibacterial activity, the GUMEFR polymer could find applications in a wide variety of fields, including biomedicine, pharmaceuticals, biocompatible materials manufacturing, as well as water purification and other industries that require materials with antimicrobial properties. Further research can be directed towards optimizing the synthesis conditions and modifying the structure of GUMEFR to enhance its biological properties and expand its application area.