Аңдатпа
The article presents the results of experiments conducted to study humoral immunity by indirect hemagglutination reaction (IHR) and cellular immunity using the method of local hemolysis to detect antibody-forming cells (ABC) according to Yerne and Nordin and the method of rosette formation of T-lymphocytes in laboratory animals immunized with dry live plague vaccine EV. The IHR test results revealed that by the 90th day post-vaccination, antibody titers in animals from Group 2, vaccinated with a dose equivalent to 20 man/doses for mice, and in animals from Group 3, vaccinated with a dose equivalent to 25 man/doses for mice, were identical. The studies conducted using the local hemolysis method to detect ABCs showed that the parenteral administration of a camel pox vaccine to white mice, at a dose equivalent to 18 man/doses, induced the production of ABCs at a level four times higher, and at 20 man/doses, five times higher than with a dose of 15 man/doses. Increasing the vaccine dose to 25 man/doses did not result in a statistically significant increase in the number of ABCs produced. The study of antigen-specific rosette formation in dynamics revealed an early increase in this index, with the highest level (12.2) recorded on the 21st day of the study in animals vaccinated with a dose equivalent to 20 man/doses.